|
KMID : 0854720100300030222
|
|
Korean Journal of Asthma, Allergy and Clinical Immunology
2010 Volume.30 No. 3 p.222 ~ p.227
|
|
|
The Stability of the Disk-type Microneedle in Skh-hairless-1 (Albino) Mice
|
|
Park Kui-Young
Lee Jin-Woong
Kim Dong-Ha
Lim Yun-Young
Kim Beom-Joon
Kim Myeung-Nam
|
|
|
Abstract
|
|
|
Background: The transdermal drug delivery system has been studied for several decades as an alternative tool. Even though it has many advantages such as stability of drug to the destination, safety to the liver, there are some limitations in crossing the stratum corneum. Microneedle can perforate the skin directly, which make it possible for drugs to penetrate into the subcutaneous tissue.
Objective: The purpose of this study to evaluate the stability of Diskmicroneedle Therapy System (DTS) and
directly compare them with conventional Microneedle Therapy System (MTSⓡ, Clinical Resolution Lab, California, USA).
Method: We used 3 sizes of manual and electric Diskmicroneedle Therapy System (DTS; 0.25 mm, 1.0 mm and
1.5 mm) to perforate the skin. We performed a comparative study of 0.5 mm manual DTS and Microneedle Therapy
System (MTSⓡ). To evaluate the stability, visual inspection and biopsy were conducted.
Result: Manual and electric DTS of all 3 sizes did not induce significant abnormalities of the skin on visual inspection and biopsy. DTS and MTS produced similar results on the stability for the skin.
Conclusion: Similar to the preexisting MTS, DTS is a safe transdermal delivery system, and the size should be chosen carefully.
|
|
|
KEYWORD
|
|
|
Diskmicroneedle therapy, Stability
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|